The team also tested a live coronavirus mutated with R203M on lung cells and found that the mutated virus induced the cells to produce 51 times more virions than the original strain of SARS-CoV-2. After measuring the brightness of cells exposed to the virus-like particles, the team concluded that a single amino acid change to the N protein “supercharged” the particles so that they delivered 10 times more mRNA into cells, Doudna tells Science. In some experiments, the team recreated the mutation R203M found in Delta’s N protein. The researchers built virus-like particles with proteins found in various SARS-CoV-2 variants to better understand how changes to those proteins affect the virus’s properties. The research team modified the virus-like particles by inserting a piece of mRNA that makes host cells glow, acting as a visual indicator of infection. Without that RNA genome the particles can’t infect cells, and thus don’t require the stringent safety protocols needed to study SARS-CoV-2 directly. While Genshin Impact gives lets you take Diluc for an early-game test drive, for those looking to make their relationship with the Winery tycoon permanent, you’ll have to get ready for a few Gacha pulls. The research team adapted a tool known as a virus-like particle, which contains the virus’s proteins but not its genome, reports Science in an article about the study. See “ Dissecting the Unusual Biology of the SARS-CoV-2 Delta Variant ”
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